Predict the ln(IC50) for a given peptide sequence


The IC50 (in nM unit) of a ligand is the concentration required to displace 50% of a reference ligand from a receptor. The receptor is a HLA-A2 MHC molecule. The reference peptide used here is ALAKAAAAV (Kd = 170 nM) for 9mers and ALAKAAAAAV (Kd = 1667 nM) for 10mers.
Note that if IC50 = 50 nM, ln(IC50) = 3.91.

Enter a 9- or 10-residue-long peptide sequence (eg. AAAAKAAAA) to predict the ln(IC50) for the HLA-A2 allele:


Send questions or comments to zhiping.weng@umassmed.edu